When I moved back to Linux from Mac, I was a bit worried about finding replacements for two programs: Garageband and iMovie. While I don’t really need those applications, I do like to create media from time to time. I’ve found replacements for both. This is the workflow I am using for my guitar.
This setup enables me to play my guitar into my headphones and add some effects. It also will do multi-track recording.
With this setup I plug my guitar right into the computer, slip on my headphones, and off I go.